Promyelocytic Leukemia Protein Potently Restricts Human Cytomegalovirus Infection in Endothelial Cells

Promyelocytic Leukemia Protein Potently Restricts Human Cytomegalovirus Infection in Endothelial Cells

PML nuclear bodies (PML-NBs) are dynamic macromolecular complexes that mediate intrinsic immunity against viruses of different families, including human cytomegalovirus (HCMV). Upon HCMV infection, PML-NBs target viral genomes entering the nucleus and restrict viral immediate–early gene expression b...

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Bibliographic Details
Main Authors: Sven Seitz, Anna Theresa Heusel, Thomas Stamminger, Myriam Scherer
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
cytomegalovirus
HCMV
endothelial cells
HEC-LTT
PML nuclear bodies
PML
Online Access:https://www.mdpi.com/1422-0067/23/19/11931

Internet

https://www.mdpi.com/1422-0067/23/19/11931

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