Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP

Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP

Abstract Background Although CD4+ memory T cells are considered the primary latent reservoir for HIV-1, replication competent HIV has been detected in tissue macrophages in both animal and human studies. During in vitro HIV infection, the depleted nucleotide pool and high dUTP levels in monocyte der...

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Bibliographic Details
Main Authors: Junru Cui, Mesfin Meshesha, Natela Churgulia, Christian Merlo, Edward Fuchs, Jennifer Breakey, Joyce Jones, James T. Stivers
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Retrovirology
Subjects:
Human HIV-1 infection
Alveolar macrophage
Monocyte
Replication competent virus
Nucleotide pools
Uracil base excision repair
Online Access:https://doi.org/10.1186/s12977-022-00607-2

Internet

https://doi.org/10.1186/s12977-022-00607-2

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