Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP
Abstract Background Although CD4+ memory T cells are considered the primary latent reservoir for HIV-1, replication competent HIV has been detected in tissue macrophages in both animal and human studies. During in vitro HIV infection, the depleted nucleotide pool and high dUTP levels in monocyte der...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2022-09-01
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Series: | Retrovirology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12977-022-00607-2 |