Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations

Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations

Background A significant proportion of individuals clinically diagnosed with familial hypercholesterolemia (FH), but without any disease‐causing mutation, are likely to have polygenic hypercholesterolemia. We evaluated the distribution of a polygenic risk score, consisting of 12 low‐density lipoprot...

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Bibliografski detalji
Glavni autori: Elena Olmastroni, Marta Gazzotti, Marcello Arca, Maurizio Averna, Angela Pirillo, Alberico Luigi Catapano, Manuela Casula
Format: Članak
Jezik:English
Izdano: Wiley 2022-04-01
Serija:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Teme:
familial hypercholesterolemia
molecular diagnosis
polygenic risk score
Online pristup:https://www.ahajournals.org/doi/10.1161/JAHA.121.023668

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.023668

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