Radical Dehalogenation and Purine Nucleoside Phosphorylase <i>E. coli</i>: How Does an Admixture of 2′,3′-Anhydroinosine Hinder 2-fluoro-cordycepin Synthesis

Radical Dehalogenation and Purine Nucleoside Phosphorylase <i>E. coli</i>: How Does an Admixture of 2′,3′-Anhydroinosine Hinder 2-fluoro-cordycepin Synthesis

During the preparative synthesis of 2-fluorocordycepin from 2-fluoroadenosine and 3′-deoxyinosine catalyzed by <i>E. coli</i> purine nucleoside phosphorylase, a slowdown of the reaction and decrease of yield down to 5% were encountered. An unknown nucleoside was found in the reaction mix...

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Bibliographic Details
Main Authors: Alexey L. Kayushin, Julia A. Tokunova, Ilja V. Fateev, Alexandra O. Arnautova, Maria Ya. Berzina, Alexander S. Paramonov, Olga I. Lutonina, Elena V. Dorofeeva, Konstantin V. Antonov, Roman S. Esipov, Igor A. Mikhailopulo, Anatoly I. Miroshnikov, Irina D. Konstantinova
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomolecules
Subjects:
purine nucleoside phosphorylase
biocatalyze
3′-deoxyinosine
2-fluorocordycepin
deuterium oxide
Online Access:https://www.mdpi.com/2218-273X/11/4/539

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https://www.mdpi.com/2218-273X/11/4/539

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