T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies
T cells are potent at eliminating pathogens and playing a crucial role in the adaptive immune response. T cell receptor (TCR) convergence describes T cells that share identical TCRs with the same amino acid sequences but have different DNA sequences due to codon degeneracy. We conducted a systematic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-11-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/81952 |
| _version_ | 1828126837685878784 |
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| author | Mingyao Pan Bo Li |
| author_facet | Mingyao Pan Bo Li |
| author_sort | Mingyao Pan |
| collection | DOAJ |
| description | T cells are potent at eliminating pathogens and playing a crucial role in the adaptive immune response. T cell receptor (TCR) convergence describes T cells that share identical TCRs with the same amino acid sequences but have different DNA sequences due to codon degeneracy. We conducted a systematic investigation of TCR convergence using single-cell immune profiling and bulk TCRβ-sequence (TCR-seq) data obtained from both mouse and human samples and uncovered a strong link between antigen-specificity and convergence. This association was stronger than T cell expansion, a putative indicator of antigen-specific T cells. By using flow-sorted tetramer+ single T cell data, we discovered that convergent T cells were enriched for a neoantigen-specific CD8+ effector phenotype in the tumor microenvironment. Moreover, TCR convergence demonstrated better prediction accuracy for immunotherapy response than the existing TCR repertoire indexes. In conclusion, convergent T cells are likely to be antigen-specific and might be a novel prognostic biomarker for anti-cancer immunotherapy. |
| first_indexed | 2024-04-11T15:41:32Z |
| format | Article |
| id | doaj.art-87d99684b3cd48ce8006276d8eaa2c38 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T15:41:32Z |
| publishDate | 2022-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-87d99684b3cd48ce8006276d8eaa2c382022-12-22T04:15:47ZengeLife Sciences Publications LtdeLife2050-084X2022-11-011110.7554/eLife.81952T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapiesMingyao Pan0https://orcid.org/0000-0003-2912-9599Bo Li1https://orcid.org/0000-0002-8617-900XLyda Hill Department of Bioinformatics, The University of Texas Southwestern Medical Center, Dallas, United StatesLyda Hill Department of Bioinformatics, The University of Texas Southwestern Medical Center, Dallas, United StatesT cells are potent at eliminating pathogens and playing a crucial role in the adaptive immune response. T cell receptor (TCR) convergence describes T cells that share identical TCRs with the same amino acid sequences but have different DNA sequences due to codon degeneracy. We conducted a systematic investigation of TCR convergence using single-cell immune profiling and bulk TCRβ-sequence (TCR-seq) data obtained from both mouse and human samples and uncovered a strong link between antigen-specificity and convergence. This association was stronger than T cell expansion, a putative indicator of antigen-specific T cells. By using flow-sorted tetramer+ single T cell data, we discovered that convergent T cells were enriched for a neoantigen-specific CD8+ effector phenotype in the tumor microenvironment. Moreover, TCR convergence demonstrated better prediction accuracy for immunotherapy response than the existing TCR repertoire indexes. In conclusion, convergent T cells are likely to be antigen-specific and might be a novel prognostic biomarker for anti-cancer immunotherapy.https://elifesciences.org/articles/81952TCR repertoireTCR convergenceimmunotherapy prognosis |
| spellingShingle | Mingyao Pan Bo Li T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies eLife TCR repertoire TCR convergence immunotherapy prognosis |
| title | T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies |
| title_full | T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies |
| title_fullStr | T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies |
| title_full_unstemmed | T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies |
| title_short | T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies |
| title_sort | t cell receptor convergence is an indicator of antigen specific t cell response in cancer immunotherapies |
| topic | TCR repertoire TCR convergence immunotherapy prognosis |
| url | https://elifesciences.org/articles/81952 |
| work_keys_str_mv | AT mingyaopan tcellreceptorconvergenceisanindicatorofantigenspecifictcellresponseincancerimmunotherapies AT boli tcellreceptorconvergenceisanindicatorofantigenspecifictcellresponseincancerimmunotherapies |