Intra-tracheal administration of a naked plasmid expressing stromal derived factor-1 improves lung structure in rodents with experimental bronchopulmonary dysplasia

Intra-tracheal administration of a naked plasmid expressing stromal derived factor-1 improves lung structure in rodents with experimental bronchopulmonary dysplasia

Abstract Background Bronchopulmonary dysplasia (BPD) is characterized by alveolar simplification and disordered angiogenesis. Stromal derived factor-1 (SDF-1) is a chemokine which modulates cell migration, proliferation, and angiogenesis. Here we tested the hypothesis that intra-tracheal (IT) admini...

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Bibliographic Details
Main Authors: Kasonya Guerra, Carleene Bryan, Frederick Dapaah-Siakwan, Ibrahim Sammour, Shelly Drummond, Ronald Zambrano, Pingping Chen, Jian Huang, Mayank Sharma, Sebastian Shrager, Merline Benny, Shu Wu, Karen C. Young
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Respiratory Research
Subjects:
Bronchopulmonary dysplasia
Hyperoxia
Angiogenesis
Stromal derived factor-1
Online Access:http://link.springer.com/article/10.1186/s12931-019-1224-6

Internet

http://link.springer.com/article/10.1186/s12931-019-1224-6

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