Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease.

Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease.

To investigate whether there is a specific dose-dependent effect of the Apolipoprotein E (APOE) ε4 and ε2 alleles on hippocampal volume, across the cognitive spectrum, from normal aging to Alzheimer's Disease (AD).We analyzed MR and genetic data on 662 patients from the Alzheimer's Disease...

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Bibliographic Details
Main Authors: Christopher A Hostage, Kingshuk Roy Choudhury, Pudugramam Murali Doraiswamy, Jeffrey R Petrella, Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3566140?pdf=render

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http://europepmc.org/articles/PMC3566140?pdf=render

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