Prospects and challenges of CAR-T cell therapy combined with ICIs

Prospects and challenges of CAR-T cell therapy combined with ICIs

Immune checkpoint molecules are a group of molecules expressed on the surface of immune cells that primarily regulate their immune homeostasis. Chimeric antigen receptor (CAR) T cell therapy is an immunotherapeutic technology that realizes tumor-targeted killing by constructing synthetic T cells exp...

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Bibliographic Details
Main Authors: Yufan Lv, Xinyu Luo, Zhuoyi Xie, Jieya Qiu, Jinsai Yang, Yuqi Deng, Rou Long, Guiyang Tang, Chaohui Zhang, Jianhong Zuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Oncology
Subjects:
immunotherapy
immune checkpoints
CAR-T cells
combination therapy
solid tumors
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1368732/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1368732/full

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