New Variants of the Cytochrome P450 2R1 (<i>CYP2R1</i>) Gene in Individuals with Severe Vitamin D-Activating Enzyme 25(OH)D Deficiency

New Variants of the Cytochrome P450 2R1 (<i>CYP2R1</i>) Gene in Individuals with Severe Vitamin D-Activating Enzyme 25(OH)D Deficiency

Background: Vitamin D is a fat-soluble cholesterol derivative found in two forms, vitamin D2, and vitamin D3. Cytochrome P450 2R1 (CYP2R1) encoded by the <i>CYP2R1</i> gene is the major hydroxylase that activates vitamin D by catalyzing the formation of 25-hydroxyvitamin D (25(OH)D). Met...

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Bibliographic Details
Main Authors: Martyna Fronczek, Joanna Katarzyna Strzelczyk, Krzysztof Biernacki, Silvia Salatino, Tadeusz Osadnik, Zofia Ostrowska
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomolecules
Subjects:
vitamin D
metabolism of vitamin D or its analogs
cytochrome P450
<i>CYP2R1</i>
25-hydroxylase
Online Access:https://www.mdpi.com/2218-273X/11/12/1867

Internet

https://www.mdpi.com/2218-273X/11/12/1867

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