Exosome miR-4738-3p-mediated regulation of COL1A2 through the NF-κB and inflammation signaling pathway alleviates osteoarthritis low-grade inflammation symptoms

Exosome miR-4738-3p-mediated regulation of COL1A2 through the NF-κB and inflammation signaling pathway alleviates osteoarthritis low-grade inflammation symptoms

This study aimed to elucidate the roles of microRNA (miR)-4738-3p and the collagen type I alpha 2 chain (COL1A2) gene in the pathogenesis of osteoarthritis (OA) through bioinformatics analysis and cellular assays. The GSE55235 dataset was analyzed using the weighted gene co-expression network analy...

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Bibliographic Details
Main Authors: Jun Xu, Kaifeng Zhou, Huijie Gu, Yiming Zhang, Liang Wu, Chong Bian, Zhongyue Huang, Guangnan Chen, Xiangyang Cheng, Xiaofan Yin
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2023-12-01
Series:Biomolecules & Biomedicine
Subjects:
Exosome
micro RNA (miR)-4739-3p
collagen type I alpha 2 chain (COL1A2)
nuclear factor kappa B (NF-κB) signaling pathway
osteoarthritis (OA)
Online Access:https://www.bjbms.org/ojs/index.php/bjbms/article/view/9921

Internet

https://www.bjbms.org/ojs/index.php/bjbms/article/view/9921

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