Phenol-Soluble Modulins From Staphylococcus aureus Biofilms Form Complexes With DNA to Drive Autoimmunity

Phenol-Soluble Modulins From Staphylococcus aureus Biofilms Form Complexes With DNA to Drive Autoimmunity

The bacterial amyloid curli, produced by Enterobacteriales including Salmonella species and Escherichia coli, is implicated in the pathogenesis of several complex autoimmune diseases. Curli binds to extracellular DNA, and these complexes drive autoimmunity via production of anti-double-stranded DNA...

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Bibliographic Details
Main Authors: Kaitlyn Grando, Lauren K. Nicastro, Sarah A. Tursi, Jaime De Anda, Ernest Y. Lee, Gerard C. L. Wong, Çağla Tükel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
PSM
Phenol Soluble Modulins
Staphycoccus aureus
biofilm
mesh
autoimmune disease
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.884065/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.884065/full

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