Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
Liu et al investigate the effects of divalent metal ions on catalysis and inhibition of the enzyme isocitrate dehydrogenase (IDH) and its cancer-linked variant R132H. They further identify the substrates for IDH as complexes with Mg2+ and show that allosteric inhibitors work by weakening Mg2+ bindin...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | English |
| Publicado: |
Nature Portfolio
2021-11-01
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| Colección: | Communications Biology |
| Acceso en línea: | https://doi.org/10.1038/s42003-021-02743-5 |