Pre-piRNA trimming safeguards piRNAs against erroneous targeting by RNA-dependent RNA polymerase
Summary: The Piwi/Piwi-interacting RNA (piRNA) pathway protects genome integrity in animal germ lines. Maturation of piRNAs involves nucleolytic processing at both 5′ and 3′ ends. The ribonuclease PARN-1 and its orthologs mediate piRNA 3′ trimming in worms, insects, and mammals. However, the signifi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-02-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724000202 |