Switching imidazole reactivity by dynamic control of tautomer state in an allosteric foldamer

Abstract Molecular biology achieves control over complex reaction networks by means of molecular systems that translate a chemical input (such as ligand binding) into an orthogonal chemical output (such as acylation or phosphorylation). We present an artificial molecular translation device that conv...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: David P. Tilly, Jean-Paul Heeb, Simon J. Webb, Jonathan Clayden
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Nature Portfolio 2023-05-01
Cyfres:Nature Communications
Mynediad Ar-lein:https://doi.org/10.1038/s41467-023-38339-2