Switching imidazole reactivity by dynamic control of tautomer state in an allosteric foldamer

Abstract Molecular biology achieves control over complex reaction networks by means of molecular systems that translate a chemical input (such as ligand binding) into an orthogonal chemical output (such as acylation or phosphorylation). We present an artificial molecular translation device that conv...

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Бібліографічні деталі
Автори: David P. Tilly, Jean-Paul Heeb, Simon J. Webb, Jonathan Clayden
Формат: Стаття
Мова:English
Опубліковано: Nature Portfolio 2023-05-01
Серія:Nature Communications
Онлайн доступ:https://doi.org/10.1038/s41467-023-38339-2