A whole blood intracellular cytokine assay optimised for field site studies demonstrates polyfunctionality of CD4+ T cells in acute scrub typhus.

A whole blood intracellular cytokine assay optimised for field site studies demonstrates polyfunctionality of CD4+ T cells in acute scrub typhus.

<h4>Background</h4>Assessment of cellular immune responses by combining intracellular cytokine staining and immunophenotyping using flow cytometry enables the simultaneous measurement of T cell phenotype and effector function in response to pathogens and vaccines. The use of whole blood...

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Bibliographic Details
Main Authors: Manutsanun Inthawong, Nattapon Pinthong, Areerat Thaiprakhong, Tri Wangrangsimakul, Piyanate Sunyakumthorn, Jennifer Hill, Piengchan Sonthayanon, Daniel H Paris, Susanna J Dunachie, Barbara Kronsteiner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-03-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0010905

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https://doi.org/10.1371/journal.pntd.0010905

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