Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption

Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption

Objective: Inspired by the traditionally clinical application of herb pair Zhimu-Huangbo to treat diabetes, a combination of plant ingredients, timosaponin B2 (TB-2) and berberine (BBR), was evaluated for their anti-diabetic efficacy and cooperative mechanisms.Methods: The efficacy and pharmacokinet...

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Bibliographic Details
Main Authors: Xiaoting Tian, Fang Liu, Zhixiong Li, Yunfei Lin, Huan Liu, Pei Hu, Mingcang Chen, Zhaolin Sun, Zhou Xu, Yiting Zhang, Li Han, Yuanyuan Zhang, Guoyu Pan, Chenggang Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Pharmacology
Subjects:
berberine
timosaponin B2
diabetes
combination treatments
drug–drug interaction
metabolites
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00019/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00019/full

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