DNA Demethylation in the Processes of Repair and Epigenetic Regulation Performed by 2-Ketoglutarate-Dependent DNA Dioxygenases

DNA Demethylation in the Processes of Repair and Epigenetic Regulation Performed by 2-Ketoglutarate-Dependent DNA Dioxygenases

Site-specific DNA methylation plays an important role in epigenetic regulation of gene expression. Chemical methylation of DNA, including the formation of various methylated nitrogenous bases, leads to the formation of genotoxic modifications that impair DNA functions. Despite the fact that differen...

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Bibliographic Details
Main Authors: Nikita A. Kuznetsov, Lyubov Yu. Kanazhevskaya, Olga S. Fedorova
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
DNA demethylation
DNA dioxygenase
oxygen activation
catalytic mechanism
direct repair
epigenetics
Online Access:https://www.mdpi.com/1422-0067/22/19/10540

Internet

https://www.mdpi.com/1422-0067/22/19/10540

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