Phentolamine Significantly Enhances Macrolide Antibiotic Antibacterial Activity against MDR Gram-Negative Bacteria

Phentolamine Significantly Enhances Macrolide Antibiotic Antibacterial Activity against MDR Gram-Negative Bacteria

Objectives: Multidrug-resistant (MDR) Gram-negative bacterial infections have limited treatment options due to the impermeability of the outer membrane. New therapeutic strategies or agents are urgently needed, and combination therapies using existing antibiotics are a potentially effective means to...

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Bibliographic Details
Main Authors: Ze-Hua Cui, Hui-Ling He, Zi-Jian Zheng, Zhao-Qi Yuan, Ying Chen, Xin-Yi Huang, Hao Ren, Yu-Feng Zhou, Dong-Hao Zhao, Liang-Xing Fang, Yang Yu, Ya-Hong Liu, Xiao-Ping Liao, Jian Sun
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Antibiotics
Subjects:
Gram-negative pathogens
phentolamine
macrolide antibiotics
synergistic antibacterial activity
Online Access:https://www.mdpi.com/2079-6382/12/4/760

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https://www.mdpi.com/2079-6382/12/4/760

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