Predicting conformational ensembles and genome-wide transcription factor binding sites from DNA sequences

Predicting conformational ensembles and genome-wide transcription factor binding sites from DNA sequences

Abstract DNA shape is emerging as an important determinant of transcription factor binding beyond just the DNA sequence. The only tool for large scale DNA shape estimates, DNAshape was derived from Monte-Carlo simulations and predicts four broad and static DNA shape features, Propeller twist, Helica...

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Bibliographic Details
Main Authors: Munazah Andrabi, Andrew Paul Hutchins, Diego Miranda-Saavedra, Hidetoshi Kono, Ruth Nussinov, Kenji Mizuguchi, Shandar Ahmad
Format: Article
Language:English
Published: Nature Portfolio 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03199-6

Internet

https://doi.org/10.1038/s41598-017-03199-6

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