Therapeutic Treatment with Pycnogenol® Attenuates Ischemic Brain Injury in Gerbils Focusing on Cognitive Impairment, Neuronal Death, BBB Leakage and Neuroinflammation in the Hippocampus

Therapeutic Treatment with Pycnogenol® Attenuates Ischemic Brain Injury in Gerbils Focusing on Cognitive Impairment, Neuronal Death, BBB Leakage and Neuroinflammation in the Hippocampus

Background: A gerbil model of ischemia and reperfusion (IR) injury in the forebrain has been developed for studies on mechanisms, prevention and therapeutic strategies of IR injury in the forebrain. Pycnogenol® (PYC), a standardized extract of French maritime pine tree (Pinus pinaster Aiton) has bee...

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Bibliographic Details
Main Authors: Tae-Kyeong Lee, Joon Ha Park, Myoung Cheol Shin, Jun Hwi Cho, Ji Hyeon Ahn, Dae Won Kim, Jae-Chul Lee, Choong-Hyun Lee, Seongkweon Hong, Moo-Ho Won, Il Jun Kang
Format: Article
Language:English
Published: IMR Press 2023-02-01
Series:Journal of Integrative Neuroscience
Subjects:
immunoglobulin g
neuroprotection
proinflammatory cytokines
pyramidal cell
transient forebrain ischemia
Online Access:https://www.imrpress.com/journal/JIN/22/2/10.31083/j.jin2202026

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https://www.imrpress.com/journal/JIN/22/2/10.31083/j.jin2202026

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