Similarities and differences in constipation phenotypes between Lep knockout mice and high fat diet-induced obesity mice.

Similarities and differences in constipation phenotypes between Lep knockout mice and high fat diet-induced obesity mice.

CRISPR-Cas9-mediated leptin (Lep) knockout (KO) mice exhibited prominent phenotypes for constipation, even though they were not compared with other model animals. This study compared the stool excretion, gastrointestinal motility, histological structure, mucin secretion, and enteric nerve function i...

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Bibliographic Details
Main Authors: Ji Eun Kim, Ayun Seol, Yun Ju Choi, Su Jin Lee, You Jeong Jin, Yu Jeong Roh, Hee Jin Song, Jin Tae Hong, Dae Youn Hwang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0276445

Internet

https://doi.org/10.1371/journal.pone.0276445

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