Combining bulk RNA-sequencing and single-cell RNA-sequencing data to reveal the immune microenvironment and metabolic pattern of osteosarcoma

Combining bulk RNA-sequencing and single-cell RNA-sequencing data to reveal the immune microenvironment and metabolic pattern of osteosarcoma

Background: Osteosarcoma (OS) is a kind of solid tumor with high heterogeneity at tumor microenvironment (TME), genome and transcriptome level. In view of the regulatory effect of metabolism on TME, this study was based on four metabolic models to explore the intertumoral heterogeneity of OS at the...

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Bibliographic Details
Main Authors: Ruichao Huang, Xiaohu Wang, Xiangyun Yin, Yaqi Zhou, Jiansheng Sun, Zhongxiu Yin, Zhi Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Genetics
Subjects:
osteosarcoma
metabolism
bulk RNA sequencing
single cell RNA sequencing
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.976990/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.976990/full

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