E-Volve: understanding the impact of mutations in SARS-CoV-2 variants spike protein on antibodies and ACE2 affinity through patterns of chemical interactions at protein interfaces

E-Volve: understanding the impact of mutations in SARS-CoV-2 variants spike protein on antibodies and ACE2 affinity through patterns of chemical interactions at protein interfaces

Background The SARS-CoV-2 pandemic reverberated, posing health and social hygiene obstacles throughout the globe. Mutant lineages of the virus have concerned scientists because of convergent amino acid alterations, mainly on the viral spike protein. Studies have shown that mutants have diminished ac...

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Bibliographic Details
Main Authors: Vitor Pimentel Dos Santos, André Rodrigues, Gabriel Dutra, Luana Bastos, Diego Mariano, José Gutembergue Mendonça, Yan Jerônimo Gomes Lobo, Eduardo Mendes, Giovana Maia, Karina dos Santos Machado, Adriano Velasque Werhli, Gerd Rocha, Leonardo Henrique França de Lima, Raquel de Melo-Minardi
Format: Article
Language:English
Published: PeerJ Inc. 2022-03-01
Series:PeerJ
Subjects:
SARS-CoV-2
Antibody
Variant
Vaccine
ACE2
Chemical interactions
Online Access:https://peerj.com/articles/13099.pdf

Internet

https://peerj.com/articles/13099.pdf

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