Processing Parameters and Ion Excipients Affect the Physicochemical Characteristics of the Stereocomplex-Formed Polylactide-b-Polyethylene Glycol Nanoparticles and Their Pharmacokinetics

Processing Parameters and Ion Excipients Affect the Physicochemical Characteristics of the Stereocomplex-Formed Polylactide-b-Polyethylene Glycol Nanoparticles and Their Pharmacokinetics

To optimize the characteristics of stereocomplex polylactide-b-polyethylene glycol nanoparticles (SC-PEG NPs) in terms of pharmacokinetics (PK), we chose continuous anti-solvent precipitation with a T-junction as a preparation method and investigated the effect of using solvents containing an ion ex...

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Bibliographic Details
Main Authors: Kohei Ogawa, Hidemasa Katsumi, Yasushi Moroto, Masaki Morishita, Akira Yamamoto
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceutics
Subjects:
polymeric nanoparticle
anti-solvent precipitations
ion excipients
flow rate
process parameters
pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/14/3/568

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https://www.mdpi.com/1999-4923/14/3/568

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