Evaluating immunological and inflammatory changes of treatment-experienced people living with HIV switching from first-line triple cART regimens to DTG/3TC vs. B/F/TAF: the DEBATE trial

Evaluating immunological and inflammatory changes of treatment-experienced people living with HIV switching from first-line triple cART regimens to DTG/3TC vs. B/F/TAF: the DEBATE trial

BackgroundThe aim of this randomized clinical trial (RCT) was to compare immunological changes in virally suppressed people living with HIV (PLWH) switching from a three-drug regimen (3DR) to a two-drug regimen (2DR).MethodsAn open-label, prospective RCT enrolling PLWH receiving a 3DR who switched t...

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Bibliographic Details
Main Authors: Andrea Cossarizza, Alessandro Cozzi-Lepri, Marco Mattioli, Annamaria Paolini, Anita Neroni, Sara De Biasi, Domenico Lo Tartaro, Rebecca Borella, Lucia Fidanza, Lara Gibellini, Barbara Beghetto, Enrica Roncaglia, Giulia Nardini, Jovana Milic, Marianna Menozzi, Gianluca Cuomo, Margherita Digaetano, Gabriella Orlando, Vanni Borghi, Giovanni Guaraldi, Cristina Mussini
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
HIV
dual regimen
three-drug regimen
DTG/3TC
B/F/TAF
CD4/CD8 ratio
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1279390/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1279390/full

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