Transgenic overexpression of the SUR2A-55 splice variant in mouse heart reduces infract size and promotes protective mitochondrial function

Transgenic overexpression of the SUR2A-55 splice variant in mouse heart reduces infract size and promotes protective mitochondrial function

ATP-sensitive potassium channels found in both the sarcolemma (sarcKATP) and mitochondria (mitoKATP) of cardiomyocytes are important mediators of cardioprotection during ischemic heart disease. Sulfonylurea receptor isoforms (SUR2), encoded by Abcc9, an ATP-binding cassette family member, form regul...

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Bibliographic Details
Main Authors: Mohun Ramratnam, Barrett Kenny, John W. Kyle, Brandi Wiedmeyer, Timothy A. Hacker, David Y. Barefield, Elizabeth M. McNally, Jonathan C. Makielski
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Heliyon
Subjects:
Medicine
Cardiology
Physiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018314610

Internet

http://www.sciencedirect.com/science/article/pii/S2405844018314610

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