Inactivation of DNA-dependent protein kinase promotes heat-induced apoptosis independently of heat-shock protein induction in human cancer cell lines.

Inactivation of DNA-dependent protein kinase promotes heat-induced apoptosis independently of heat-shock protein induction in human cancer cell lines.

The inhibition of DNA damage response pathway seems to be an attractive strategy for cancer therapy. It was previously reported that in rodent cells exposed to heat stress, cell growth was promoted by the activity of DNA-dependent protein kinase (DNA-PK), an enzyme involved in DNA non-homologous end...

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Bibliographic Details
Main Authors: Seisuke Okazawa, Yukihiro Furusawa, Ayako Kariya, Mariame Ali Hassan, Mie Arai, Ryuji Hayashi, Yoshiaki Tabuchi, Takashi Kondo, Kazuyuki Tobe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3594312?pdf=render

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http://europepmc.org/articles/PMC3594312?pdf=render

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