Endogenous osteoprotegerin (OPG) represses ERα and promotes stemness and chemoresistance in breast cancer cells

Abstract Breast cancer (BC) is the most prevalent cancer and the leading cause of death among women worldwide. The osteoprotegerin (OPG) cytokine, a decoy receptor for RANKL and a key player in bone homeostasis, has pro-and anti-carcinogenic effects in various types of cancer, including breast neopl...

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Bibliographic Details
Main Authors: Noura N. Alraouji, Dilek Colak, Falah H. Al-mohanna, Ayodele A. Alaiya, Abdelilah Aboussekhra
Format: Article
Language:English
Published: Nature Publishing Group 2024-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02151-8