Breaking the selectivity-uptake trade-off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi-tier cancer targeting

Breaking the selectivity-uptake trade-off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi-tier cancer targeting

Abstract Background Photoimmunotherapy involves targeted delivery of photosensitizers via an antibody conjugate (i.e., photoimmunoconjugate, PIC) followed by light activation for selective tumor killing. The trade-off between PIC selectivity and PIC uptake is a major drawback limiting the efficacy o...

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Bibliographic Details
Main Authors: Barry J. Liang, Michael Pigula, Yan Baglo, Daniel Najafali, Tayyaba Hasan, Huang-Chiao Huang
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Nanobiotechnology
Subjects:
Photoimmunoconjugate
Irinotecan liposome injection
Benzoporphyrin derivative
Epidermal growth factor receptor
Multi-drug delivery
Online Access:https://doi.org/10.1186/s12951-019-0560-5

Internet

https://doi.org/10.1186/s12951-019-0560-5

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