Breaking the selectivity-uptake trade-off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi-tier cancer targeting
Abstract Background Photoimmunotherapy involves targeted delivery of photosensitizers via an antibody conjugate (i.e., photoimmunoconjugate, PIC) followed by light activation for selective tumor killing. The trade-off between PIC selectivity and PIC uptake is a major drawback limiting the efficacy o...
Main Authors: | Barry J. Liang, Michael Pigula, Yan Baglo, Daniel Najafali, Tayyaba Hasan, Huang-Chiao Huang |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-01-01
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Series: | Journal of Nanobiotechnology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12951-019-0560-5 |
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