Bioavailability and pharmacokinetic comparison of tanshinones between two formulations of Salvia miltiorrhiza in healthy volunteers

Abstract Salvia miltiorrhiza (SM) is widely used to treat microcirculatory disturbance-related diseases; its lipophilic components play important roles in this application. Cryptotanshinone (CTS), tanshinone I (TSI) and tanshinone IIA (TSA) are the most widely-studied lipophilic ingredients, but low...

Full description

Bibliographic Details
Main Authors: Lu Xing, Zhi-Rong Tan, Jin-Le Cheng, Wei-Hua Huang, Wei Zhang, Wen Deng, Chun-Su Yuan, Hong-Hao Zhou
Format: Article
Language:English
Published: Nature Portfolio 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02747-4