Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging

Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging

Aging leads to a loss of vasomotor control. Both vasodilation and vasoconstriction are affected. Decreased nitric oxide–cGMP-mediated relaxation is a hallmark of aging. It contributes to vascular disease, notably hypertension, infarction, and dementia. Decreased vasodilation can be caused by aging i...

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Bibliographic Details
Main Authors: Keivan Golshiri, Ehsan Ataei Ataabadi, Renata Brandt, Ingrid van der Pluijm, René de Vries, A. H. Jan Danser, Anton Roks
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
phosphodiesterase
sildenafil
aging
cGMP
nitric oxide
vascular dysfunction
Online Access:https://www.mdpi.com/1422-0067/21/13/4667

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https://www.mdpi.com/1422-0067/21/13/4667

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