A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model.

A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model.

Hedgehog (Hh) signaling is over-activated in several solid tumors where it plays a central role in cell growth, stroma recruitment and tumor progression. In the Hh signaling pathway, the Smoothened (SMO) receptor comprises a primary drug target with experimental small molecule SMO antagonists curren...

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Bibliographic Details
Main Authors: Martin F Strand, Steven R Wilson, Jennifer L Dembinski, Daniel D Holsworth, Alexander Khvat, Ilya Okun, Dirk Petersen, Stefan Krauss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3115942?pdf=render

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http://europepmc.org/articles/PMC3115942?pdf=render

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