Evaluation of In-Batch and In-Flow Synthetic Strategies towards the Stereoselective Synthesis of a Fluorinated Analogue of Retro-Thiorphan

Evaluation of In-Batch and In-Flow Synthetic Strategies towards the Stereoselective Synthesis of a Fluorinated Analogue of Retro-Thiorphan

A stereoselective synthetic strategy for the preparation of trifluoromethylamine mimics of retro-thiorphan, involving a diastereoselective, metal-free catalytic step, has been studied in batch and afforded the target molecule in good yields and high diastereoselectivity. A crucial point of the synth...

Full description

Bibliographic Details
Main Authors: Margherita Pirola, Alessandra Puglisi, Laura Raimondi, Alessandra Forni, Maurizio Benaglia
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
fluorinated derivatives
flow chemistry
organocatalysis
stereoselective synthesis
reduction
Online Access:https://www.mdpi.com/1420-3049/24/12/2260

Internet

https://www.mdpi.com/1420-3049/24/12/2260

Similar Items