Extension of the Generalized Disequilibrium Test to polytomous phenotypes and two-locus models

We extend the usual logistic model between a dichotomous phenotype and an allele count in two ways: a polytomous phenotype with K > 2 levels, and modelling of allele counts at two unlinked marker loci. Inference is based on within-family information to guard against potential bias due to populati...

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Bibliographic Details
Main Authors: Alexandre eBureau, Jordie eCroteau, Yvon eChagnon, Marc-André eRoy, Michel eMaziade
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Genetics
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00258/full