Precise epigenomic editing with a SunTag-based modular epigenetic toolkit

Precise epigenomic editing with a SunTag-based modular epigenetic toolkit

Epigenetic regulation is a crucial factor controlling gene expression. Here, we report our CRISPR/dCas9-based modular epigenetic toolkit that enables gene-specific modulation of epigenetic architecture. By modifying the SunTag framework of dCas9 tagged with five GCN4 moieties, each epigenetic writer...

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Bibliographic Details
Main Authors: Subhrangshu Guhathakurta, Levi Adams, Inhye Jeong, Anishaa Sivakumar, Mingyu Cha, Mariana Bernardo Fiadeiro, Haiyan Nancy Hu, Yoon-Seong Kim
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Epigenetics
Subjects:
epigenetics
histone post-translational modifications
epigenome editing
crispr
epigenetic writers
Online Access:http://dx.doi.org/10.1080/15592294.2022.2106646

Internet

http://dx.doi.org/10.1080/15592294.2022.2106646

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