Epidermal growth factor receptor inhibition with erlotinib partially prevents cisplatin-induced nephrotoxicity in rats.

Epidermal growth factor receptor inhibition with erlotinib partially prevents cisplatin-induced nephrotoxicity in rats.

The effects of blocking the epidermal growth factor receptor (EGFR) in acute kidney injury (AKI) are controversial. Here we investigated the renoprotective effect of erlotinib, a selective tyrosine kinase inhibitor that can block EGFR activity, on cisplatin (CP)-induced AKI. Groups of animals were g...

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Bibliographic Details
Main Authors: Yukihiro Wada, Masayuki Iyoda, Kei Matsumoto, Yuki Shindo-Hirai, Yoshihiro Kuno, Yasutaka Yamamoto, Taihei Suzuki, Tomohiro Saito, Ken Iseri, Takanori Shibata
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4229108?pdf=render

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http://europepmc.org/articles/PMC4229108?pdf=render

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