Declined adipogenic potential of senescent MSCs due to shift in insulin signaling and altered exosome cargo

Declined adipogenic potential of senescent MSCs due to shift in insulin signaling and altered exosome cargo

Multipotent mesenchymal stromal cells (MSCs) maintain cellular homeostasis and regulate tissue renewal and repair both by differentiating into mesodermal lineage, e.g., adipocytes, or managing the functions of differentiated cells. Insulin is a key physiological inducer of MSC differentiation into a...

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Main Authors: Elizaveta Voynova, Konstantin Kulebyakin, Olga Grigorieva, Ekaterina Novoseletskaya, Natalia Basalova, Natalia Alexandrushkina, Mikhail Arbatskiy, Maxim Vigovskiy, Anna Sorokina, Anna Zinoveva, Elizaveta Bakhchinyan, Natalia Kalinina, Zhanna Akopyan, Vsevolod Tkachuk, Pyotr Tyurin-Kuzmin, Anastasia Efimenko
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
senescence
extracellular vesicles (EVs)
insulin signaling
adipogenic potential
MSCs (mesenchymal stromal cells)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1050489/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.1050489/full

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