Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.

Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.

Human immunodeficiency virus type 1 (HIV-1) infects macrophages effectively, despite relatively low levels of cell surface-expressed CD4. Although HIV-1 infections are defined by viral tropisms according to chemokine receptor usage (R5 and X4), variations in infection are common within both R5- and...

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Bibliographic Details
Main Authors: Zhongcheng Zou, Ashley Chastain, Susan Moir, Jennifer Ford, Kathryn Trandem, Elena Martinelli, Claudia Cicala, Paul Crocker, James Arthos, Peter D Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3169630?pdf=render

Internet

http://europepmc.org/articles/PMC3169630?pdf=render

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