Frequency of CXCR3+ CD8+ T-Lymphocyte Subsets in Peripheral Blood Is Associated With the Risk of Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Development in Advanced HIV Disease

Frequency of CXCR3+ CD8+ T-Lymphocyte Subsets in Peripheral Blood Is Associated With the Risk of Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Development in Advanced HIV Disease

BackgroundTuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a clinical aggravation of TB symptoms observed among a fraction of HIV coinfected patients shortly after the start of antiretroviral therapy (ART). Of note, TB-IRIS is characterized by exacerbated inflammation...

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Main Authors: Rafael Tibúrcio, Gopalan Narendran, Beatriz Barreto-Duarte, Artur T. L. Queiroz, Mariana Araújo-Pereira, Selvaraj Anbalagan, Kaustuv Nayak, Narayanan Ravichandran, Rajasekaran Subramani, Lis R. V. Antonelli, Kumar Satagopan, Komathi Anbalagan, Brian O. Porter, Alan Sher, Soumya Swaminathan, Irini Sereti, Bruno B. Andrade
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
TB-IRIS
immunologic memory
CD8+ T cells
naïve lymphocytes
M. tuberculosis infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.873985/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.873985/full

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