Characterization of a Reservoir-Style Implant for Sustained Release of Tenofovir Alafenamide (TAF) for HIV Pre-Exposure Prophylaxis (PrEP)

Characterization of a Reservoir-Style Implant for Sustained Release of Tenofovir Alafenamide (TAF) for HIV Pre-Exposure Prophylaxis (PrEP)

Long-acting (LA) HIV pre-exposure prophylaxis (PrEP) offers the potential to improve adherence by lowering the burden of daily or on-demand regimens of antiretroviral (ARV) drugs. This paper details the fabrication and in vitro performance of a subcutaneous and trocar-compatible implant for the LA d...

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Bibliographic Details
Main Authors: Leah M. Johnson, Sai Archana Krovi, Linying Li, Natalie Girouard, Zach R. Demkovich, Daniel Myers, Ben Creelman, Ariane van der Straten
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Pharmaceutics
Subjects:
poly(ε-caprolactone) (PCL)
tenofovir alafenamide (TAF)
pre-exposure prophylaxis (PrEP)
long-acting drug delivery systems
implant
Online Access:https://www.mdpi.com/1999-4923/11/7/315

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https://www.mdpi.com/1999-4923/11/7/315

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