Overexpression of TRPV1 activates autophagy in human lens epithelial cells under hyperosmotic stress through Ca2+-dependent AMPK/mTOR pathway

Overexpression of TRPV1 activates autophagy in human lens epithelial cells under hyperosmotic stress through Ca2+-dependent AMPK/mTOR pathway

AIM: To explore whether autophagy functions as a cellular adaptation mechanism in lens epithelial cells (LECs) under hyperosmotic stress. METHODS: LECs were treated with hyperosmotic stress at the concentration of 270, 300, 400, 500, or 600 mOsm for 6, 12, 18, 24h in vitro. Polymerase chain reaction...

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Bibliographic Details
Main Authors: Liu-Hui Huang, Jiao Lyu, Sheng Chen, Ting-Yi Liang, Yu-Qing Rao, Ping Fei, Jing Li, Hai-Ying Jin, Pei-Quan Zhao
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2024-03-01
Series:International Journal of Ophthalmology
Subjects:
cataract
posterior capsular opacification
lens epithelial cell
hyperosmotic stress
autophagy
apoptosis
transient receptor potential vanilloid 1
Online Access:http://ies.ijo.cn/en_publish/2024/3/20240303.pdf

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http://ies.ijo.cn/en_publish/2024/3/20240303.pdf

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