Human-Based Immune Responsive In Vitro Infection Models for Validation of Novel TLR4 Antagonists Identified by Computational Discovery

Human-Based Immune Responsive In Vitro Infection Models for Validation of Novel TLR4 Antagonists Identified by Computational Discovery

Infectious diseases are still a major problem worldwide. This includes microbial infections, with a constant increase in resistance to the current anti-infectives employed. Toll-like receptors (TLRs) perform a fundamental role in pathogen recognition and activation of the innate immune response. Pro...

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Bibliographic Details
Main Authors: Helena Merk, Tehila Amran-Gealia, Doris Finkelmeier, Christina Kohl, Isabelle Pichota, Noa Stern, Steffen Rupp, Amiram Goldblum, Anke Burger-Kentischer
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Microorganisms
Subjects:
3D-immune-competent Infection models
<i>Candida albicans</i>
Toll-like receptors
antagonist
pharmacophore
docking
Online Access:https://www.mdpi.com/2076-2607/10/2/243

Internet

https://www.mdpi.com/2076-2607/10/2/243

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