Deciphering the role of CX3CL1-CX3CR1 in aortic aneurysm pathogenesis: insights from Mendelian randomization and transcriptomic analyses

Deciphering the role of CX3CL1-CX3CR1 in aortic aneurysm pathogenesis: insights from Mendelian randomization and transcriptomic analyses

BackgroundThe crucial role of inflammation in aortic aneurysm (AA) is gaining prominence, while there is still a lack of key cytokines or targets for effective clinical translation.MethodsMendelian randomization (MR) analysis was performed to identify the causal relationship between 91 circulating i...

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Bibliographic Details
Main Authors: Xingyu Qian, Yidan Zheng, Li Xu, Zongtao Liu, Ming Chen, Fuqiang Tong, Pengning Fan, Zhe Chen, Nianguo Dong, Chao Zhang, Junwei Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
aortic aneurysm
Mendelian randomization
single-cell RNA sequencing
cytokine
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1383607/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1383607/full

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