RORγt+ c-Maf+ Vγ4+ γδ T cells are generated in the adult thymus but do not reach the periphery

RORγt+ c-Maf+ Vγ4+ γδ T cells are generated in the adult thymus but do not reach the periphery

Summary: T cell receptor (TCR) Vγ4-expressing γδ T cells comprise interferon γ (IFNγ)- and interleukin-17 (IL-17)-producing effector subsets, with a preference for IL-17 effector fate decisions during early ontogeny. The existence of adult-thymus-derived IL-17+ T cells (γδ17) remains controversial....

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Bibliographic Details
Main Authors: Tao Yang, Joana Barros-Martins, Ziqing Wang, Melanie Wencker, Jiang Zhang, Justine Smout, Prerna Gambhir, Anika Janssen, Anja Schimrock, Hristo Georgiev, Ximena León-Lara, Siegfried Weiss, Jochen Huehn, Immo Prinz, Andreas Krueger, Reinhold Foerster, Thierry Walzer, Sarina Ravens
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723012421

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http://www.sciencedirect.com/science/article/pii/S2211124723012421

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