Postacute administration of the GABA α5 antagonist S44819 promotes recovery of peripheral limb fine motor skills after permanent distal middle cerebral artery occlusion in rats

Postacute administration of the GABA α5 antagonist S44819 promotes recovery of peripheral limb fine motor skills after permanent distal middle cerebral artery occlusion in rats

Background: Ischemic stroke causes hypoexcitability in the peri-infarct motor neocortex that stems from increased tonic γ-amino-butyric acid (GABA) activity in neurons. This hypoexcitability, while neuroprotective in the acute phase, may impair neuroplasticity and functional recovery in the subacute...

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Bibliographic Details
Main Authors: Marta Pace, Matteo Falappa, Patricia Machado, Laura Facchin, Dirk M Hermann, Claudio L Bassetti
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Clinical and Translational Neuroscience
Online Access:https://doi.org/10.1177/2514183X20948306

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https://doi.org/10.1177/2514183X20948306

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