Human equivalent dose of oral 4-aminopyridine differentiates nerve crush injury from transection injury and improves post-injury function in mice

Human equivalent dose of oral 4-aminopyridine differentiates nerve crush injury from transection injury and improves post-injury function in mice

4-Aminopyridine (4-AP), an FDA-approved drug for the symptomatic treatment of multiple sclerosis, is used to improve neuromuscular function in patients with diverse demyelinating disorders. We recently demonstrated that local, transdermal or injectable forms of 4-AP improve myelination, nerve conduc...

Full description

Bibliographic Details
Main Authors: Chia George Hsu, M A Hassan Talukder, Li Yue, Loel C Turpin, Mark Noble, John C Elfar
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
4-aminopyridine; electron microscopy of nerves; functional recovery; gene expression; muscle force; muscle mass; oral administration; pharmacokinetics; sciatic nerve crush injury; sciatic nerve denervation injury
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=11;spage=2098;epage=2107;aulast=Hsu

Internet

http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=11;spage=2098;epage=2107;aulast=Hsu

Similar Items