Colorectal cancer in patients of advanced age is associated with increased incidence of BRAF p.V600E mutation and mismatch repair deficiency

Colorectal cancer in patients of advanced age is associated with increased incidence of BRAF p.V600E mutation and mismatch repair deficiency

IntroductionThe highest incidence of colorectal cancer (CRC) is in patients diagnosed at 80 years or older highlighting a need for understanding the clinical and molecular features of these tumors. Methods. In this retrospective cohort study, 544 CRCs underwent next generation sequencing and mismatc...

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Bibliographic Details
Main Authors: Eric S. Christenson, Hua-Ling Tsai, Dung T. Le, Elizabeth M. Jaffee, Jonathan Dudley, Rena R. Xian, Christopher D. Gocke, James R. Eshleman, Ming-Tseh Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Oncology
Subjects:
mismatch repair (MMR) deficiency
colorectal cancer
BRAF mutation V600E
late onset colorectal cancer
APC mutations
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1193259/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1193259/full

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